E-submission
Search
- Page Path
- HOME > Search
Original Article
- Histologic Disorderliness in the Arrangement of Tumor Cells as an Objective Measure of Tumor Differentiation
- Sungwook Suh, Gyeongsin Park, Young Sub Lee, Yosep Chong, Youn Soo Lee, Yeong Jin Choi
- Korean J Pathol. 2014;48(5):339-345. Published online October 27, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.339
- 6,001 View
- 50 Download
-
Abstract
PDF - Background: Inter-observer and intra-observer variation in histologic tumor grading are well documented. To determine whether histologic disorderliness in the arrangement of tumor cells may serve as an objective criterion for grading, we tested the hypothesis the degree of disorderliness is related to the degree of tumor differentiation on which tumor grading is primarily based. Methods: Borrowing from the statistical thermodynamic definition of entropy, we defined a novel mathematical formula to compute the relative degree of histologic disorderliness of tumor cells. We then analyzed a total of 51 photomicrographs of normal colorectal mucosa and colorectal adenocarcinoma with varying degrees of differentiation using our formula. Results: A one-way analysis of variance followed by post hoc pairwise comparisons using Bonferroni correction indicated that the mean disorderliness score was the lowest for the normal colorectal mucosa and increased with decreasing tumor differentiation. Conclusions: Disorderliness, a pathologic feature of malignant tumors that originate from highly organized structures is useful as an objective tumor grading proxy in the field of digital pathology.
Brief Case Report
- Fine Needle Aspiration Cytology of Warthin-like Papillary Thyroid Carcinoma: A Brief Case Report
- Yosep Chong, Sungwook Suh, Tae-Jung Kim, Eun Jung Lee
- Korean J Pathol. 2014;48(2):170-173. Published online April 28, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.170
- 7,545 View
- 38 Download
- 10 Crossref
-
PDF
-
Citations
Citations to this article as recorded by
- Warthin-like variant of papillary thyroid carcinoma with lymph node metastases: a case report and review of the literature
Andrii Hryshchyshyn, Andrii Bahrii, Pavlina Botsun, Volodymyr Chuba
Journal of Medical Case Reports.2024;[Epub] CrossRef - The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases
Xing Zhao, Yijia Zhang, Pengyu Hao, Mingzhen Zhao, Xingbin Shen
Oncologie.2023; 25(5): 581. CrossRef - Solid papillary thyroid carcinoma with Hashimoto’s thyroiditis: description of a further case with challenging cytological features
Franco Fulciniti, Jessica Barizzi, Pierpaolo Trimboli, Luca Giovanella
BMJ Case Reports.2019; 12(1): e226153. CrossRef - Preoperative Cytologic Diagnosis of Warthin-like Variant of Papillary Thyroid Carcinoma
Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo
Journal of Pathology and Translational Medicine.2018; 52(2): 105. CrossRef - Warthin like papillary carcinoma - A rare variant of papillary carcinoma thyroid
Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat Bashir
Human Pathology: Case Reports.2018; 13: 21. CrossRef - Cytological features of warthin‐like papillary thyroid carcinoma: A case report with review of previous cytology cases
Archana George Vallonthaiel, Shipra Agarwal, Deepali Jain, Rajni Yadav, Nishikant A. Damle
Diagnostic Cytopathology.2017; 45(9): 837. CrossRef - Comparison of EASYPREP® and SurePath® in thyroid fine‐needle aspiration
Yosep Chong, Ki Hyun Baek, Jee Young Kim, Tae‐Jung Kim, Eun Jung Lee, Chang Suk Kang
Diagnostic Cytopathology.2016; 44(4): 283. CrossRef - Ultrasonographic features and clinical characteristics of Warthin-like variant of papillary thyroid carcinoma
Ga Ram Kim, Jung Hee Shin, Soo Yeon Hahn, Eun Young Ko, Young Lyun Oh
Endocrine Journal.2016; 63(4): 329. CrossRef - Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis
Karla Judith González-Colunga, Abelardo Loya-Solis, Luis Ángel Ceceñas-Falcón, Oralia Barboza-Quintana, René Rodríguez-Gutiérrez
Case Reports in Endocrinology.2015; 2015: 1. CrossRef - Tumeur Warthin-like de la thyroïde : à propos d’un cas
W. Rekik, A. Khadhar, A. Zehani, H. Azouz, I. Chelly, T. Ben Ghachem, A. Sellem, M. Tounsi, H. Ben Mahjouba, S. Haouet, N. Kchir
Journal Africain du Cancer / African Journal of Cancer.2015; 7(4): 247. CrossRef
- Warthin-like variant of papillary thyroid carcinoma with lymph node metastases: a case report and review of the literature
First
Prev
